Title |
Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44
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Published in |
Blood, June 2005
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DOI | 10.1182/blood-2004-12-4802 |
Pubmed ID | |
Authors |
Anja Fuchs, Marina Cella, Takayuki Kondo, Marco Colonna |
Abstract |
Natural killer (NK) cell-mediated cytotoxicity is triggered by multiple activating receptors associated with the signaling adaptor protein DNAX activation protein 12/killer cell-activating receptor-associated protein (DAP12/KARAP). Here, we show that one of these receptors, NKp44, is present on a subset of natural interferon-producing cells (IPCs) in tonsils. NKp44 expression can also be induced on blood IPCs after in vitro culture with interleukin 3 (IL-3). Crosslinking of NKp44 does not trigger IPC-mediated cytotoxicity but, paradoxically, inhibits interferon alpha (IFN-alpha) production by IPCs in response to cytosine-phosphate-guanosine (CpG) oligonucleotides. We find that IPCs in tonsils are in close contact with CD8+ T cells and demonstrate that a subset of memory CD8+ T cells produces IL-3. Therefore, IL-3-mediated induction of NKp44 on IPCs may be an important component of the ongoing crosstalk between the innate and adaptive immune response that allows memory CD8+ T cells to control the IPC response to virus. |
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Other | 5 | 7% |
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Other | 8 | 12% |
Unknown | 11 | 16% |
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