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Mendeley readers
Attention Score in Context
| Title |
Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44
|
|---|---|
| Published in |
Blood, June 2005
|
| DOI | 10.1182/blood-2004-12-4802 |
| Pubmed ID | |
| Authors |
Anja Fuchs, Marina Cella, Takayuki Kondo, Marco Colonna |
| Abstract |
Natural killer (NK) cell-mediated cytotoxicity is triggered by multiple activating receptors associated with the signaling adaptor protein DNAX activation protein 12/killer cell-activating receptor-associated protein (DAP12/KARAP). Here, we show that one of these receptors, NKp44, is present on a subset of natural interferon-producing cells (IPCs) in tonsils. NKp44 expression can also be induced on blood IPCs after in vitro culture with interleukin 3 (IL-3). Crosslinking of NKp44 does not trigger IPC-mediated cytotoxicity but, paradoxically, inhibits interferon alpha (IFN-alpha) production by IPCs in response to cytosine-phosphate-guanosine (CpG) oligonucleotides. We find that IPCs in tonsils are in close contact with CD8+ T cells and demonstrate that a subset of memory CD8+ T cells produces IL-3. Therefore, IL-3-mediated induction of NKp44 on IPCs may be an important component of the ongoing crosstalk between the innate and adaptive immune response that allows memory CD8+ T cells to control the IPC response to virus. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 3% |
| Colombia | 1 | 1% |
| Italy | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 63 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 25% |
| Researcher | 14 | 21% |
| Student > Master | 10 | 15% |
| Other | 5 | 7% |
| Student > Bachelor | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 11 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 29% |
| Immunology and Microbiology | 19 | 28% |
| Medicine and Dentistry | 7 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Chemistry | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 12 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2023.
All research outputs
#3,798,945
of 25,374,917 outputs
Outputs from Blood
#4,890
of 33,238 outputs
Outputs of similar age
#7,491
of 67,727 outputs
Outputs of similar age from Blood
#29
of 197 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,238 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,727 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 197 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.