| Title |
Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia
|
|---|---|
| Published in |
Archives of Dermatological Research, March 2018
|
| DOI | 10.1007/s00403-018-1826-8 |
| Pubmed ID | |
| Authors |
A. Premanand, B. Reena Rajkumari |
| Abstract |
Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/β-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia. Here, we analyse the androgen-induced dermal papilla secreted factors on stimulating catagen entry in hair follicles and the molecular cross-talk between AR and Wnt/β-catenin signaling with a brief mention on alternative treatment strategy targeting Wnt/β-catenin signaling for promoting hair growth. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 13% |
| Researcher | 10 | 12% |
| Student > Master | 9 | 10% |
| Student > Ph. D. Student | 7 | 8% |
| Student > Postgraduate | 5 | 6% |
| Other | 9 | 10% |
| Unknown | 35 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 22% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Agricultural and Biological Sciences | 5 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Economics, Econometrics and Finance | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 36 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2018.
All research outputs
#18,594,219
of 23,031,582 outputs
Outputs from Archives of Dermatological Research
#1,099
of 1,328 outputs
Outputs of similar age
#258,890
of 333,160 outputs
Outputs of similar age from Archives of Dermatological Research
#7
of 9 outputs
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So far Altmetric has tracked 1,328 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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