| Title |
Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma
|
|---|---|
| Published in |
Clinical & Experimental Metastasis, May 2007
|
| DOI | 10.1007/s10585-007-9070-1 |
| Pubmed ID | |
| Authors |
Mikio Terauchi, Hiroaki Kajiyama, Mamoru Yamashita, Mikihiko Kato, Hirohisa Tsukamoto, Tomokazu Umezu, Satoyo Hosono, Eiko Yamamoto, Kiyosumi Shibata, Kazuhiko Ino, Akihiro Nawa, Tetsuro Nagasaka, Fumitaka Kikkawa |
| Abstract |
Loss of E-cadherin triggers peritoneal dissemination, leading to an adverse prognosis for most patients with epithelial ovarian carcinoma (EOC). Because TWIST mainly regulates the epithelial-to-mesenchymal transition and is one of the E-cadherin repressors, we investigated the possibility that TWIST expression affects peritoneal metastasis of EOC using siRNA technique. In the present study, we showed a correlation between TWIST expression and EOC cellular morphology. Furthermore, we demonstrated that the suppression of TWIST expression in EOC cells (HEY) alters the cellular morphology from a fibroblastic and motile phenotype to an epithelial phenotype, and inhibits the adhesion of these cells to mesothelial monolayers. To investigate the mechanism by which down-regulation of TWIST leads to inhibition of adhesion to mesothelial cells (MCs), expression of adhesion molecules (CD29, CD44 and CD54) were observed. Moreover, matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase, important markers associated with invasive and metastatic potential, were remarkably reduced. This findings suggests that reduced expression of TWIST suppresses the multistep process of peritoneal dissemination (detachment from the primary lesion, adhesion to MCs and invasion of MCs) and may be a potential therapeutic target for the treatment of this carcinoma. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 7% |
| Portugal | 1 | 3% |
| Unknown | 27 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 30% |
| Researcher | 5 | 17% |
| Student > Bachelor | 3 | 10% |
| Lecturer | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 27% |
| Agricultural and Biological Sciences | 8 | 27% |
| Biochemistry, Genetics and Molecular Biology | 5 | 17% |
| Nursing and Health Professions | 2 | 7% |
| Business, Management and Accounting | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 6 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2008.
All research outputs
#7,917,073
of 23,854,458 outputs
Outputs from Clinical & Experimental Metastasis
#210
of 778 outputs
Outputs of similar age
#26,229
of 73,552 outputs
Outputs of similar age from Clinical & Experimental Metastasis
#2
of 5 outputs
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