Title |
Effects of IGFBP-2 overexpression in vitro and in vivo
|
---|---|
Published in |
Pediatric Nephrology, June 2000
|
DOI | 10.1007/s004670000362 |
Pubmed ID | |
Authors |
E. Wolf, H. Lahm, M. Wu, R. Wanke, A. Hoeflich |
Abstract |
Insulin-like growth factor-binding proteins (IGFBPs) are important modulators of IGF actions and may have both stimulatory and inhibitory effects. Expression of IGFBP-2 is increased after fasting and in a variety of pathological conditions. However, the specific role of IGFBP-2 in growth physiology remains to be determined. In this review, we summarize data from in vitro and in vivo models suggesting that IGFBP-2 has mainly inhibitory effects on IGF actions. Since the growth hormone (GH)/IGF system is involved in a number of pathological alterations of the kidney and these changes may--at least in part--be due to increased IGF-I, local overexpression of inhibitory IGFBP-2 in the kidney might prevent IGF-I-induced lesions. This hypothesis will be tested by crossing GH transgenic mice, a common model of glomerulosclerosis, with transgenic mice characterized by systemic and renal overexpression of IGFBP-2. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 17% |
Student > Doctoral Student | 3 | 13% |
Professor | 2 | 8% |
Student > Bachelor | 1 | 4% |
Other | 3 | 13% |
Unknown | 5 | 21% |
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Immunology and Microbiology | 1 | 4% |
Other | 1 | 4% |
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