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Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation

Overview of attention for article published in Molecular Psychiatry, November 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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1 patent
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2 Wikipedia pages

Citations

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68 Dimensions

Readers on

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101 Mendeley
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1 CiteULike
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Title
Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation
Published in
Molecular Psychiatry, November 2009
DOI 10.1038/mp.2009.120
Pubmed ID
Authors

T C Bates, P A Lind, M Luciano, G W Montgomery, N G Martin, M J Wright

Abstract

The status of DYX1C1 (C15q21.3) as a susceptibility gene for dyslexia is unclear. We report the association of this gene with reading and spelling ability in a sample of adolescent twins and their siblings. Family-based association analyses were carried out on 13 single-nucleotide polymorphisms (SNPs) in DYX1C1, typed in 790 families with up to 5 offspring and tested on 6 validated measures of lexical processing (irregular word) and grapheme-phoneme decoding (pseudo-word) reading- and spelling-based measures of dyslexia, as well as a short-term memory measure. Significant association was observed at the misssense mutation rs17819126 for all reading measures and for spelling of lexical processing words, and at rs3743204 for both irregular and nonword reading. Verbal short-term memory was associated with rs685935. Support for association was not found at rs3743205 and rs61761345 as previously reported by Taipale et al., but these SNPs had very low (0.002 for rs3743205) minor allele frequencies in this sample. These results suggest that DYX1C1 influences reading and spelling ability with additional effects on short-term information storage or rehearsal. Missense mutation rs17819126 is a potential functional basis for the association of DYX1C1 with dyslexia.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
United States 1 <1%
China 1 <1%
Unknown 98 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 15%
Researcher 13 13%
Student > Master 13 13%
Professor 10 10%
Student > Bachelor 10 10%
Other 24 24%
Unknown 16 16%
Readers by discipline Count As %
Psychology 22 22%
Agricultural and Biological Sciences 22 22%
Biochemistry, Genetics and Molecular Biology 14 14%
Medicine and Dentistry 7 7%
Engineering 4 4%
Other 14 14%
Unknown 18 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2018.
All research outputs
#4,696,560
of 22,788,370 outputs
Outputs from Molecular Psychiatry
#2,324
of 4,105 outputs
Outputs of similar age
#18,697
of 93,479 outputs
Outputs of similar age from Molecular Psychiatry
#11
of 27 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,105 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,479 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.