| Title |
Interplay between carbon, nitrogen and phosphate utilization in the control of secondary metabolite production in Streptomyces
|
|---|---|
| Published in |
Antonie van Leeuwenhoek, March 2018
|
| DOI | 10.1007/s10482-018-1073-1 |
| Pubmed ID | |
| Authors |
Alba Romero-Rodríguez, Nidia Maldonado-Carmona, Beatriz Ruiz-Villafán, Niranjan Koirala, Diana Rocha, Sergio Sánchez |
| Abstract |
Streptomyces species are a wide and diverse source of many therapeutic agents (antimicrobials, antineoplastic and antioxidants, to name a few) and represent an important source of compounds with potential applications in medicine. The effect of nitrogen, phosphate and carbon on the production of secondary metabolites has long been observed, but it was not until recently that the molecular mechanisms on which these effects rely were ascertained. In addition to the specific macronutrient regulatory mechanisms, there is a complex network of interactions between these mechanisms influencing secondary metabolism. In this article, we review the recent advances in our understanding of the molecular mechanisms of regulation exerted by nitrogen, phosphate and carbon sources, as well as the effects of their interconnections, on the synthesis of secondary metabolites by members of the genus Streptomyces. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 16% |
| Student > Master | 14 | 15% |
| Student > Ph. D. Student | 12 | 13% |
| Researcher | 9 | 10% |
| Professor | 5 | 5% |
| Other | 11 | 12% |
| Unknown | 28 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 24% |
| Agricultural and Biological Sciences | 18 | 19% |
| Immunology and Microbiology | 7 | 7% |
| Medicine and Dentistry | 4 | 4% |
| Engineering | 3 | 3% |
| Other | 9 | 10% |
| Unknown | 30 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2018.
All research outputs
#18,594,219
of 23,031,582 outputs
Outputs from Antonie van Leeuwenhoek
#1,628
of 2,037 outputs
Outputs of similar age
#256,392
of 329,958 outputs
Outputs of similar age from Antonie van Leeuwenhoek
#33
of 41 outputs
Altmetric has tracked 23,031,582 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,037 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,958 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.