Title |
Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis
|
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Published in |
Reproductive Biology and Endocrinology, March 2018
|
DOI | 10.1186/s12958-018-0346-x |
Pubmed ID | |
Authors |
Kailin Yang, Liuting Zeng, Tingting Bao, Jinwen Ge |
Abstract |
To assess the effectiveness and safety of omega-3 fatty acid for patients with PCOS. In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of omega-3 fatty acid versus placebo or western medicine in women with PCOS. The study's registration number is CRD42017065859. The primary outcomes included the change of homeostatic model assessment (HOMA) of insulin resistance, total cholesterol (TC), triglyceride (TG) and adiponectin. Nine trials involving 591 patients were included. Comparing with the control group, omega-3 fatty acid may improve HOMA index (WMD -0.80; 95% CI -0.89, - 0.71; P<0. 00001), decrease TC and TG level [TC: (WMD -9.43; 95% CI -11.90, - 6.95; P<0. 00001); TG: (WMD -29.21; 95% CI -48.08, - 10.34; P = 0. 002)], and increase adiponectin level (WMD 1.34; 95% CI 0.51, 2.17; P = 0. 002). Based on current evidence, omega-3 fatty acid may be recommended for the treatment of PCOS with insulin resistance as well as high TC (especially LDL-C) and TG. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 215 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 46 | 21% |
Student > Master | 20 | 9% |
Student > Doctoral Student | 17 | 8% |
Researcher | 16 | 7% |
Student > Postgraduate | 12 | 6% |
Other | 17 | 8% |
Unknown | 87 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 23% |
Nursing and Health Professions | 42 | 20% |
Biochemistry, Genetics and Molecular Biology | 8 | 4% |
Agricultural and Biological Sciences | 6 | 3% |
Social Sciences | 5 | 2% |
Other | 11 | 5% |
Unknown | 93 | 43% |