| Title |
Human Genome and Diseases:¶WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, December 2001
|
| DOI | 10.1007/pl00000838 |
| Pubmed ID | |
| Authors |
D. Li, R. Roberts |
| Abstract |
Defined by the presence of four or more repeating units containing a conserved core of approximately 40 amino acids that usually ending with tryptophan-aspartic acid (WD), WD-repeat proteins belong to a large and fast-expanding conservative protein family. As demonstrated by the crystal structure of the G protein beta subunit, all WD-repeat proteins are speculated to form a circularized beta propeller structure. The importance of these proteins is not only demonstrated by their critical roles in many essential biological functions ranging from signal transduction, transcription regulation, to apoptosis, but is also recognized by their association with several human diseases. Defining the function of a WD-repeat protein is the current challenge. It is, however, paramount to uncover the function of individual WD-repeat proteins, explore the protein interaction mechanism through WD-repeat domains and, ultimately, understand the complex biological processes and organisms themselves. |
Mendeley readers
The data shown below were compiled from readership statistics for 274 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 5 | 2% |
| United Kingdom | 2 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 262 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 62 | 23% |
| Student > Master | 38 | 14% |
| Student > Bachelor | 38 | 14% |
| Researcher | 35 | 13% |
| Student > Doctoral Student | 12 | 4% |
| Other | 33 | 12% |
| Unknown | 56 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 91 | 33% |
| Biochemistry, Genetics and Molecular Biology | 85 | 31% |
| Chemistry | 9 | 3% |
| Medicine and Dentistry | 7 | 3% |
| Neuroscience | 6 | 2% |
| Other | 18 | 7% |
| Unknown | 58 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from Cellular and Molecular Life Sciences
#2,146
of 5,877 outputs
Outputs of similar age
#32,691
of 132,013 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#6
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,877 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,013 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.