| Title |
Structural genomics as an approach towards understanding the biology of tuberculosis
|
|---|---|
| Published in |
Journal of Structural and Functional Genomics, August 2007
|
| DOI | 10.1007/s10969-007-9020-9 |
| Pubmed ID | |
| Authors |
Edward N. Baker |
| Abstract |
Tuberculosis (TB) is a devastating disease of worldwide importance. The availability of the genome sequence of Mycobacterium tuberculosis (Mtb), the causative agent, has stimulated a large variety of genome-scale initiatives. These include international structural genomics efforts which have the dual aim of characterising potential new drug targets and addressing key aspects of the biology of Mtb. This review highlights the various ways in which structural analysis has illuminated the biological activities of Mtb gene products, which were previously of unknown or uncertain function. Key information comes from the protein fold, from bound ligands, solvent molecules, ions etc. or from unexpectedly modified amino acid residues. Most importantly, the three dimensional structure of a protein permits the integration of data from many sources, both bioinformatic and experimental, to develop testable functional hypotheses. This has led to many new insights into TB biology. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 2 | 13% |
| India | 1 | 6% |
| Unknown | 13 | 81% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 31% |
| Student > Ph. D. Student | 4 | 25% |
| Other | 2 | 13% |
| Professor | 2 | 13% |
| Student > Master | 1 | 6% |
| Other | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 50% |
| Biochemistry, Genetics and Molecular Biology | 4 | 25% |
| Chemical Engineering | 1 | 6% |
| Computer Science | 1 | 6% |
| Chemistry | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 1 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2008.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Journal of Structural and Functional Genomics
#26
of 107 outputs
Outputs of similar age
#24,347
of 67,032 outputs
Outputs of similar age from Journal of Structural and Functional Genomics
#2
of 2 outputs
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So far Altmetric has tracked 107 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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