| Title |
Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population
|
|---|---|
| Published in |
Archives of Dermatological Research, June 2006
|
| DOI | 10.1007/s00403-006-0670-4 |
| Pubmed ID | |
| Authors |
Sen Yang, Kai-Lin Yan, Xue-Jun Zhang, Feng-Li Xiao, Xing Fan, Min Gao, Yong Cui, Peng-Guang Wang, Guo-Long Zhang, Liang-Dan Sun, Zhi-Min Wang, Da-Zhi Wang, Kai-Yue Zhang, Wei Huang, Jian-Jun Liu |
| Abstract |
Several recent studies have demonstrated the possible involvement of the microsomal glutathione S-transferase 2 (MGST2) gene in the pathogenesis of psoriasis. The objectives of this work are to determine whether the genetic polymorphisms of the MGST2 gene were associated with an increased risk of psoriasis in Chinese patients. We first characterized the linkage disequilibrium pattern within MGST2 and identified single-nucleotide polymorphisms (SNPs) for tagging common genetic variants. Genotype- and haplotype-based analyses were then performed by genotyping the Tag SNPs in a large-scale sample of cases and controls. We characterized the linkage disequilibrium pattern within MGST2 using 12 densely distributed SNPs and identified 6 SNPs for tagging common genetic variants. We then performed an association analysis by genotyping the six SNPs in 552 cases and 384 controls, but none of the genotype- and haplotype-based analyses revealed significant evidence for association. We also performed family-based association analysis by genotyping the six SNPs in 95 trios; no evidence for association was identified. Our comprehensive genetic analysis of MGST2 common variants in a large Chinese sample of psoriasis did not provide any supporting evidence for MGST2 to be the susceptibility gene within the PSORS9 locus. |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 46% |
| Professor | 2 | 15% |
| Student > Ph. D. Student | 2 | 15% |
| Student > Master | 1 | 8% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 23% |
| Agricultural and Biological Sciences | 3 | 23% |
| Medicine and Dentistry | 3 | 23% |
| Chemistry | 1 | 8% |
| Materials Science | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 2 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2008.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Archives of Dermatological Research
#331
of 1,325 outputs
Outputs of similar age
#22,616
of 64,442 outputs
Outputs of similar age from Archives of Dermatological Research
#3
of 6 outputs
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