| Title |
High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2)
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, September 2005
|
| DOI | 10.1007/s11010-005-5535-1 |
| Pubmed ID | |
| Authors |
Yunfeng Li, Yongsheng Chang, Lifeng Zhang, Qiping Feng, Zhuo Liu, Yongwei Zhang, Jin Zuo, Yan Meng, Fude Fang |
| Abstract |
A new Rattus norvegicus PanK gene was isolated by mRNA differential display from high concentration glucose-stimulated rat, which encodes a human PanK4-like protein with KOG2201 and KOG4584 domain. Proteins that interact with rat PanK4 were identified by the application of the yeast two-hybrid system. One of the components, Pkm2, was found to be associated with rat PanK4 and its two domains under both in vitro and in vivo conditions. Immunofluorescence staining and confocal scanning experiments showed that PanK4 could transiently co-express with Pkm2 in the cytoplasm of HeLa cell and HEK293T cell. These findings suggest that PanK4 interacts with Pkm2 and thereby may modulate the glucose metabolism through regulating the activity of Pkm2. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 25% |
| Student > Ph. D. Student | 6 | 19% |
| Student > Bachelor | 3 | 9% |
| Lecturer | 2 | 6% |
| Professor | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 7 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 38% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Immunology and Microbiology | 1 | 3% |
| Chemistry | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 10 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2008.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Molecular and Cellular Biochemistry
#417
of 2,302 outputs
Outputs of similar age
#20,395
of 58,592 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#4
of 16 outputs
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