You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Ligand-Dependent Nuclear Receptor Corepressor LCoR Functions by Histone Deacetylase-Dependent and -Independent Mechanisms
|
|---|---|
| Published in |
Molecular Cell, January 2003
|
| DOI | 10.1016/s1097-2765(03)00014-5 |
| Pubmed ID | |
| Authors |
Isabelle Fernandes, Yolande Bastien, Timothy Wai, Karen Nygard, Roberto Lin, Olivier Cormier, Han S. Lee, Frankie Eng, Nicholas R. Bertos, Nadine Pelletier, Sylvie Mader, Victor K.M. Han, Xiang-Jiao Yang, John H. White |
| Abstract |
LCoR (ligand-dependent corepressor) is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LXXLL motif. LCoR binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2. Repression by LCoR is abolished by histone deacetylase inhibitor trichostatin A in a receptor-dependent fashion, indicating HDAC-dependent and -independent modes of action. LCoR binds directly to specific HDACs in vitro and in vivo. Moreover, LCoR functions by recruiting C-terminal binding protein corepressors through two consensus binding motifs and colocalizes with CtBPs in the nucleus. LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 119 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 26% |
| Researcher | 24 | 20% |
| Student > Bachelor | 10 | 8% |
| Professor > Associate Professor | 9 | 7% |
| Student > Master | 7 | 6% |
| Other | 20 | 16% |
| Unknown | 21 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 41% |
| Biochemistry, Genetics and Molecular Biology | 29 | 24% |
| Medicine and Dentistry | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Environmental Science | 2 | 2% |
| Other | 7 | 6% |
| Unknown | 24 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2018.
All research outputs
#5,446,629
of 25,373,627 outputs
Outputs from Molecular Cell
#4,079
of 7,617 outputs
Outputs of similar age
#15,774
of 136,759 outputs
Outputs of similar age from Molecular Cell
#18
of 56 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,759 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.