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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
|
|---|---|
| Published in |
Nature Cell Biology, January 2000
|
| DOI | 10.1038/35000025 |
| Pubmed ID | |
| Authors |
Amparo Cano, Mirna A. Pérez-Moreno, Isabel Rodrigo, Annamaria Locascio, María J. Blanco, Marta G. del Barrio, Francisco Portillo, M. Angela Nieto |
| Abstract |
The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal transitions) during embryonic development. Epithelial-mesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelial-mesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Philippines | 1 | 33% |
| Spain | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,282 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 1% |
| United Kingdom | 6 | <1% |
| Spain | 4 | <1% |
| Italy | 4 | <1% |
| Germany | 3 | <1% |
| Japan | 3 | <1% |
| Switzerland | 2 | <1% |
| France | 2 | <1% |
| Austria | 1 | <1% |
| Other | 9 | <1% |
| Unknown | 1235 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 314 | 24% |
| Student > Master | 176 | 14% |
| Researcher | 163 | 13% |
| Student > Bachelor | 160 | 12% |
| Student > Doctoral Student | 78 | 6% |
| Other | 169 | 13% |
| Unknown | 222 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 420 | 33% |
| Biochemistry, Genetics and Molecular Biology | 347 | 27% |
| Medicine and Dentistry | 131 | 10% |
| Engineering | 25 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 2% |
| Other | 92 | 7% |
| Unknown | 247 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2024.
All research outputs
#1,615,962
of 26,017,215 outputs
Outputs from Nature Cell Biology
#884
of 4,184 outputs
Outputs of similar age
#1,908
of 112,322 outputs
Outputs of similar age from Nature Cell Biology
#1
of 27 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,184 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,322 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.