| Title |
Inflammation, a significant player of Ataxia–Telangiectasia pathogenesis?
|
|---|---|
| Published in |
Inflammation Research, March 2018
|
| DOI | 10.1007/s00011-018-1142-y |
| Pubmed ID | |
| Authors |
Majid Zaki-Dizaji, Seyed Mohammad Akrami, Gholamreza Azizi, Hassan Abolhassani, Asghar Aghamohammadi |
| Abstract |
Ataxia-Telangiectasia (A-T) syndrome is an autosomal recessive neurodegenerative disorder characterized by cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, chromosome instability, radiosensitivity, and predisposition to malignancy. There is growing evidence that A-T patients suffer from pathologic inflammation that is responsible for many symptoms of this syndrome, including neurodegeneration, autoimmunity, cardiovascular disease, accelerated aging, and insulin resistance. In addition, epidemiological studies have shown A-T heterozygotes, somewhat like deficient patients, are susceptible to ionizing irradiation and have a higher risk of cancers and metabolic disorders. This review summarizes clinical and molecular findings of inflammation in A-T syndrome. Ataxia-Telangiectasia Mutated (ATM), a master regulator of the DNA damage response is the protein known to be associated with A-T and has a complex nuclear and cytoplasmic role. Loss of ATM function may induce immune deregulation and systemic inflammation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 17% |
| Researcher | 3 | 10% |
| Other | 2 | 7% |
| Student > Bachelor | 2 | 7% |
| Lecturer | 2 | 7% |
| Other | 4 | 14% |
| Unknown | 11 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 21% |
| Immunology and Microbiology | 3 | 10% |
| Neuroscience | 3 | 10% |
| Medicine and Dentistry | 3 | 10% |
| Nursing and Health Professions | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 13 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2018.
All research outputs
#15,498,204
of 23,031,582 outputs
Outputs from Inflammation Research
#625
of 960 outputs
Outputs of similar age
#210,834
of 330,393 outputs
Outputs of similar age from Inflammation Research
#6
of 10 outputs
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So far Altmetric has tracked 960 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
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