| Title |
Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL
|
|---|---|
| Published in |
Immunogenetics, July 2011
|
| DOI | 10.1007/s00251-011-0554-4 |
| Pubmed ID | |
| Authors |
Baojun Wu, Meng Jin, Yi Zhang, Tiandi Wei, Zengliang Bai |
| Abstract |
The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have been identified in non-mammalian species, such as zebrafish IL17RD; however, there are no reports on the evolutionary history of this complex gene family through comparative phylogenetic approaches. Here, we concentrated on the IL17R evolution in chordates. There are two IL17Rs in the genome of the basal chordate amphioxus: IL17RA and IL17RD. After two rounds of whole genome duplications, these two IL17R genes expanded into five early vertebrate IL17R genes, IL17RA to IL17RE. IL17RA and IL17RD are found in most vertebrates, whereas the other three, IL17RB, ILR17RC, and IL17RE, underwent some loss in vertebrates during evolution. Our sequence and structure analyses reveal functional similarities and distinctions between the different IL17Rs. Based on similarity searches for IL17R-like proteins within chordate sequences, a group of IL17RE-like (IL17REL) proteins were identified from mammalians to lower vertebrates. In silico and expression analyses on the novel IL17RELs showed that this group of receptors is highly conserved across species, indicating that IL17REL may represent a unique subfamily of IL17Rs. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 29 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 33% |
| Researcher | 9 | 30% |
| Student > Master | 4 | 13% |
| Student > Doctoral Student | 2 | 7% |
| Student > Bachelor | 2 | 7% |
| Other | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 43% |
| Biochemistry, Genetics and Molecular Biology | 8 | 27% |
| Immunology and Microbiology | 3 | 10% |
| Neuroscience | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Other | 2 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2011.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Immunogenetics
#323
of 1,202 outputs
Outputs of similar age
#41,625
of 116,342 outputs
Outputs of similar age from Immunogenetics
#4
of 10 outputs
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