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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A multidrug resistance transporter from human MCF-7 breast cancer cells
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, December 1998
|
| DOI | 10.1073/pnas.95.26.15665 |
| Pubmed ID | |
| Authors |
L. Austin Doyle, Weidong Yang, Lynne V. Abruzzo, Tammy Krogmann, Yongming Gao, Arun K. Rishi, Douglas D. Ross |
| Abstract |
MCF-7/AdrVp is a multidrug-resistant human breast cancer subline that displays an ATP-dependent reduction in the intracellular accumulation of anthracycline anticancer drugs in the absence of overexpression of known multidrug resistance transporters such as P glycoprotein or the multidrug resistance protein. RNA fingerprinting led to the identification of a 2.4-kb mRNA that is overexpressed in MCF-7/AdrVp cells relative to parental MCF-7 cells. The mRNA encodes a 655-aa [corrected] member of the ATP-binding cassette superfamily of transporters that we term breast cancer resistance protein (BCRP). Enforced expression of the full-length BCRP cDNA in MCF-7 breast cancer cells confers resistance to mitoxantrone, doxorubicin, and daunorubicin, reduces daunorubicin accumulation and retention, and causes an ATP-dependent enhancement of the efflux of rhodamine 123 in the cloned transfected cells. BCRP is a xenobiotic transporter that appears to play a major role in the multidrug resistance phenotype of MCF-7/AdrVp human breast cancer cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 650 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Poland | 2 | <1% |
| Japan | 2 | <1% |
| Italy | 2 | <1% |
| Ireland | 1 | <1% |
| Indonesia | 1 | <1% |
| India | 1 | <1% |
| Other | 10 | 2% |
| Unknown | 625 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 152 | 23% |
| Student > Master | 114 | 18% |
| Student > Bachelor | 83 | 13% |
| Researcher | 64 | 10% |
| Student > Doctoral Student | 41 | 6% |
| Other | 90 | 14% |
| Unknown | 106 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 158 | 24% |
| Biochemistry, Genetics and Molecular Biology | 135 | 21% |
| Medicine and Dentistry | 81 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 61 | 9% |
| Chemistry | 40 | 6% |
| Other | 54 | 8% |
| Unknown | 121 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2021.
All research outputs
#3,515,553
of 25,837,817 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#36,211
of 103,917 outputs
Outputs of similar age
#5,346
of 111,595 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#64
of 405 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103,917 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,595 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 405 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.