| Title |
Inactivation dates of the human and guinea pig vitamin C genes
|
|---|---|
| Published in |
Genetica, December 2010
|
| DOI | 10.1007/s10709-010-9537-x |
| Pubmed ID | |
| Authors |
Marc Y. Lachapelle, Guy Drouin |
| Abstract |
The capacity to biosynthesize ascorbic acid has been lost in a number of species including primates, guinea pigs, teleost fishes, bats, and birds. This inability results from mutations in the GLO gene coding for L-gulono-γ-lactone oxidase, the enzyme responsible for catalyzing the last step in the vitamin C biosynthetic pathway. We analyzed available primate and rodent GLO gene sequences to determine their evolutionary history. We used a method based on sequence comparisons of lineages with and without functional GLO genes to calculate inactivation dates of 61 and 14 MYA for the primate and guinea pig genes, respectively. These estimates are consistent with previous phylogeny-based estimates. An analysis of transposable element distribution in the primate and rodent GLO sequences did not reveal conclusive evidence that illegitimate recombination between repeats has contributed to the loss of exons in the primate and guinea pig genes. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Latvia | 1 | 13% |
| United Kingdom | 1 | 13% |
| Norway | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Practitioners (doctors, other healthcare professionals) | 3 | 38% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Sweden | 1 | 1% |
| Unknown | 80 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 18% |
| Student > Ph. D. Student | 13 | 16% |
| Student > Master | 12 | 15% |
| Researcher | 7 | 9% |
| Professor | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 18 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 26% |
| Biochemistry, Genetics and Molecular Biology | 12 | 15% |
| Medicine and Dentistry | 5 | 6% |
| Chemistry | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 13 | 16% |
| Unknown | 24 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2023.
All research outputs
#688,659
of 25,708,267 outputs
Outputs from Genetica
#5
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Outputs of similar age
#2,839
of 192,849 outputs
Outputs of similar age from Genetica
#1
of 16 outputs
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So far Altmetric has tracked 712 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 99% of its peers.
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