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Mendeley readers
Attention Score in Context
| Title |
STK11/LKB1 Peutz-Jeghers Gene Inactivation in Intraductal Papillary-Mucinous Neoplasms of the Pancreas
|
|---|---|
| Published in |
American Journal of Pathology, December 2001
|
| DOI | 10.1016/s0002-9440(10)63053-2 |
| Pubmed ID | |
| Authors |
Norihiro Sato, Christophe Rosty, Marnix Jansen, Noriyoshi Fukushima, Takashi Ueki, Charles J. Yeo, John L. Cameron, Christine A. Iacobuzio-Donahue, Ralph H. Hruban, Michael Goggins |
| Abstract |
Despite the growing awareness of intraductal papillary-mucinous neoplasms (IPMNs) of the pancreas among clinicians, the molecular features of IPMNs have not been well characterized. Previous reports suggest that inactivation of the STK11/LKB1, a tumor-suppressor gene responsible for Peutz-Jeghers syndrome (PJS), plays a role in the pathogenesis of gastrointestinal hamartomas as well as several cancers, including pancreatic adenocarcinoma. Using polymerase chain reaction amplification of five microsatellite markers from the 19p13.3 region harboring the STK11/LKB1 gene, we analyzed DNA from 22 IPMNs for loss of heterozygosity (LOH). LOH at 19p13.3 was identified in 2 of 2 (100%) IPMNs from patients with PJS and 5 of 20 (25%) from patients lacking features of PJS (7 of 22, 32% overall). Sequencing analysis of the STK11/LKB1 gene in these IPMNs with LOH revealed a germline mutation in one IPMN that arose in a patient with PJS and a somatic mutation in 1 of the 20 sporadic IPMNs. None of the 22 IPMNs showed hypermethylation of the STK11/LKB1 gene. These results suggest that the STK11/LKB1 gene is involved in the pathogenesis of some IPMNs. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 17% |
| Student > Ph. D. Student | 8 | 11% |
| Student > Master | 6 | 8% |
| Student > Bachelor | 6 | 8% |
| Professor > Associate Professor | 5 | 7% |
| Other | 15 | 21% |
| Unknown | 19 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 32% |
| Agricultural and Biological Sciences | 12 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Environmental Science | 1 | 1% |
| Arts and Humanities | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 21 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2021.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from American Journal of Pathology
#2,307
of 5,904 outputs
Outputs of similar age
#32,691
of 132,007 outputs
Outputs of similar age from American Journal of Pathology
#29
of 70 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,904 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.