| Title |
RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?
|
|---|---|
| Published in |
Chromosome Research, March 2009
|
| DOI | 10.1007/s10577-008-9018-6 |
| Pubmed ID | |
| Authors |
Eri Kinoshita, Eddy van der Linden, Humberto Sanchez, Claire Wyman |
| Abstract |
The protein complex including Mre11, Rad50, and Nbs1 (MRN) functions in DNA double-strand break repair to recognize and process DNA ends as well as signal for cell cycle arrest. Amino acid sequence similarity and overall architecture make Rad50 a member of the structural maintenance of chromosome (SMC) protein family. Like SMC proteins, Rad50 function depends on ATP binding and hydrolysis. All current evidence indicates that ATP binding and hydrolysis cause architectural rearrangements in SMC protein complexes that are important for their functions in organizing DNA. In the case of the MRN complex, the functional significance of ATP binding and hydrolysis are not yet defined. Here we review the data on the ATP-dependent activities of MRN and their possible mechanistic significance. We present some speculation on the role of ATP for function of the MRN complex based on the similarities and differences in the molecular architecture of the Rad50-containing complexes and the SMC complexes condensin and cohesin. |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 1% |
| Bulgaria | 1 | 1% |
| Czechia | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 94 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 27% |
| Student > Ph. D. Student | 19 | 19% |
| Student > Master | 10 | 10% |
| Professor > Associate Professor | 7 | 7% |
| Student > Bachelor | 7 | 7% |
| Other | 10 | 10% |
| Unknown | 19 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 42% |
| Biochemistry, Genetics and Molecular Biology | 28 | 29% |
| Medicine and Dentistry | 3 | 3% |
| Environmental Science | 1 | 1% |
| Nursing and Health Professions | 1 | 1% |
| Other | 6 | 6% |
| Unknown | 18 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2022.
All research outputs
#7,463,719
of 22,818,766 outputs
Outputs from Chromosome Research
#145
of 507 outputs
Outputs of similar age
#32,601
of 93,259 outputs
Outputs of similar age from Chromosome Research
#1
of 2 outputs
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