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Mendeley readers
Attention Score in Context
| Title |
Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)
|
|---|---|
| Published in |
The Journal of Immunology, April 2004
|
| DOI | 10.4049/jimmunol.172.7.3994 |
| Pubmed ID | |
| Authors |
Anja Fuchs, Marina Cella, Emanuele Giurisato, Andrey S. Shaw, Marco Colonna |
| Abstract |
The poliovirus receptor (PVR) belongs to a large family of Ig molecules called nectins and nectin-like proteins, which mediate cell-cell adhesion, cell migration, and serve as entry receptors for viruses. It has been recently shown that human NK cells recognize PVR through the receptor DNAM-1, which triggers NK cell stimulation in association with beta(2) integrin. In this study, we show that NK cells recognize PVR through an additional receptor, CD96, or T cell-activated increased late expression (Tactile). CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. Thus, NK cells have evolved a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cell adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 2% |
| United States | 2 | 1% |
| France | 1 | <1% |
| Singapore | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 159 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 19% |
| Researcher | 31 | 19% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 16 | 10% |
| Professor > Associate Professor | 9 | 5% |
| Other | 29 | 17% |
| Unknown | 31 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 42 | 25% |
| Agricultural and Biological Sciences | 34 | 20% |
| Biochemistry, Genetics and Molecular Biology | 27 | 16% |
| Medicine and Dentistry | 21 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 7 | 4% |
| Unknown | 32 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#2,394,121
of 26,017,215 outputs
Outputs from The Journal of Immunology
#801
of 30,365 outputs
Outputs of similar age
#3,478
of 67,358 outputs
Outputs of similar age from The Journal of Immunology
#7
of 236 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 30,365 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,358 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 236 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.