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Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)

Overview of attention for article published in The Journal of Immunology, April 2004
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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44 patents
wikipedia
3 Wikipedia pages

Citations

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289 Dimensions

Readers on

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159 Mendeley
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Title
Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)
Published in
The Journal of Immunology, April 2004
DOI 10.4049/jimmunol.172.7.3994
Pubmed ID
Authors

Anja Fuchs, Marina Cella, Emanuele Giurisato, Andrey S. Shaw, Marco Colonna

Abstract

The poliovirus receptor (PVR) belongs to a large family of Ig molecules called nectins and nectin-like proteins, which mediate cell-cell adhesion, cell migration, and serve as entry receptors for viruses. It has been recently shown that human NK cells recognize PVR through the receptor DNAM-1, which triggers NK cell stimulation in association with beta(2) integrin. In this study, we show that NK cells recognize PVR through an additional receptor, CD96, or T cell-activated increased late expression (Tactile). CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. Thus, NK cells have evolved a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cell adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 2%
United States 2 1%
France 1 <1%
Singapore 1 <1%
United Kingdom 1 <1%
Unknown 151 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 19%
Researcher 23 14%
Student > Master 20 13%
Student > Bachelor 16 10%
Professor > Associate Professor 9 6%
Other 29 18%
Unknown 31 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 21%
Immunology and Microbiology 34 21%
Biochemistry, Genetics and Molecular Biology 27 17%
Medicine and Dentistry 21 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 7 4%
Unknown 32 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#2,330,607
of 25,377,790 outputs
Outputs from The Journal of Immunology
#770
of 29,907 outputs
Outputs of similar age
#3,303
of 64,953 outputs
Outputs of similar age from The Journal of Immunology
#6
of 232 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 29,907 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 64,953 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 232 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.