Title |
Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus
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Published in |
BMC Genomics, January 2005
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DOI | 10.1186/1471-2164-6-4 |
Pubmed ID | |
Authors |
Andrew S McLellan, Beate Fischer, Gabriela Dveksler, Tomomi Hori, Freda Wynne, Melanie Ball, Katsuzumi Okumura, Tom Moore, Wolfgang Zimmermann |
Abstract |
The pregnancy-specific glycoprotein (Psg) genes encode proteins of unknown function, and are members of the carcinoembryonic antigen (Cea) gene family, which is a member of the immunoglobulin gene (Ig) superfamily. In rodents and primates, but not in artiodactyls (even-toed ungulates / hoofed mammals), there have been independent expansions of the Psg gene family, with all members expressed exclusively in placental trophoblast cells. For the mouse Psg genes, we sought to determine the genomic organisation of the locus, the expression profiles of the various family members, and the evolution of exon structure, to attempt to reconstruct the evolutionary history of this locus, and to determine whether expansion of the gene family has been driven by selection for increased gene dosage, or diversification of function. |
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Unknown | 40 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 18% |
Researcher | 7 | 16% |
Student > Bachelor | 5 | 11% |
Student > Doctoral Student | 4 | 9% |
Professor | 4 | 9% |
Other | 12 | 27% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 22% |
Immunology and Microbiology | 7 | 16% |
Medicine and Dentistry | 3 | 7% |
Computer Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 6 | 13% |