| Title |
Molecular cloning and characterization of AAAS-V2, a novel splice variant of human AAAS
|
|---|---|
| Published in |
Molecular Biology Reports, June 2005
|
| DOI | 10.1007/s11033-004-6939-9 |
| Pubmed ID | |
| Authors |
Xin Li, Chaoneng Ji, Jiefeng Gu, Jian Xu, Zhe Jin, Liyun Sun, Xianqiong Zou, Yun Lin, Ruping Sun, Peng Wang, Shaohua Gu, Yumin Mao |
| Abstract |
Triple-A syndrome (MIM 231550; also known as Allgrove syndrome) is an autosomal recessive disorder characterized by adrenocorticotropin hormone (ACTH)-resistant adrenal insufficiency, achalasia of the oesophageal cardia and alacrima. Much initial molecular analysis supported that Triple-A syndrome was caused by mutations in AAAS, a WD-repeat protein gene. Here we report cloning and characterization of a novel splice variant of human AAAS, which we named AAAS-v2, which is located on the human chromosome 12p13. The cDNA is 1703 bp, encoding a 513-amino acid polypeptide, which contains three WD40 domains, one less than the original which we called AAAS-v1 (Gen Bank: NM_015665.3). RT-PCR analysis in our work revealed that AAAS-v2 and AAAS-v1 were ubiquitously detected in human multiple tissue cDNA (MTC) panels (CLONTECH). |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 7% |
| Unknown | 13 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 21% |
| Student > Master | 3 | 21% |
| Other | 2 | 14% |
| Professor | 2 | 14% |
| Student > Doctoral Student | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 1 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 36% |
| Biochemistry, Genetics and Molecular Biology | 3 | 21% |
| Medicine and Dentistry | 3 | 21% |
| Engineering | 1 | 7% |
| Unknown | 2 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2015.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Molecular Biology Reports
#389
of 2,907 outputs
Outputs of similar age
#20,300
of 57,225 outputs
Outputs of similar age from Molecular Biology Reports
#1
of 3 outputs
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