| Title |
Immunohistochemical analysis of SOX6 expression in human brain tumors
|
|---|---|
| Published in |
Brain Tumor Pathology, October 2004
|
| DOI | 10.1007/bf02482186 |
| Pubmed ID | |
| Authors |
Ryo Ueda, Kazunari Yoshida, Yutaka Kawakami, Takeshi Kawase, Masahiro Toda |
| Abstract |
We previously demonstrated that the developmentally regulated gene, SOX6, is strongly expressed in glioma cells and in the fetal brain, but only faintly in the normal adult brain. Recent studies have indicated that brain tumor cells may share antigens, signaling systems, and behavior with neural stem/progenitor cells. To test the validity of this proposition, we analyzed the expression of SOX6 in various human central nervous system (CNS) tumors. Immunohistochemical analysis revealed that astrocytic and oligodendroglial tumors expressed SOX6; neuronal-glial cell tumors (central neurocytoma) and embryonal tumors (medulloblastoma), which arise from multipotential stem cell precursors, also showed a high intensity of SOX6 staining. In contrast, ependymal tumors (ependymoma and subependymoma), meningioma, and schwannoma, which are all well differentiated tumors, showed either no staining or only faint staining for SOX6. These results suggest that SOX6 may be expressed in bipotential or multipotential cells capable of neuronal and glial differentiation, but not in fully differentiated cells. SOX6 may be a useful marker for the diagnosis of tumors arising from immature bipotential cells that may differentiate into neuronal and glial cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 18% |
| Student > Bachelor | 2 | 12% |
| Student > Doctoral Student | 2 | 12% |
| Professor > Associate Professor | 2 | 12% |
| Lecturer | 1 | 6% |
| Other | 4 | 24% |
| Unknown | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 29% |
| Agricultural and Biological Sciences | 3 | 18% |
| Neuroscience | 3 | 18% |
| Immunology and Microbiology | 1 | 6% |
| Unknown | 5 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2023.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Brain Tumor Pathology
#23
of 169 outputs
Outputs of similar age
#19,776
of 61,139 outputs
Outputs of similar age from Brain Tumor Pathology
#1
of 2 outputs
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