| Title |
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma
|
|---|---|
| Published in |
Acta Neuropathologica, May 2006
|
| DOI | 10.1007/s00401-006-0033-4 |
| Pubmed ID | |
| Authors |
Kazuhiko Mishima, Yukinari Kato, Mika K. Kaneko, Youya Nakazawa, Akiko Kunita, Naoya Fujita, Takashi Tsuruo, Ryo Nishikawa, Takanori Hirose, Masao Matsutani |
| Abstract |
Podoplanin, a mucin-like transmembrane sialoglycoprotein, promotes platelet aggregation and may be involved in cancer cell migration, invasion, metastasis, and malignant progression. Podoplanin/aggrus is highly expressed in testicular seminoma, suggesting that it may be a sensitive marker for testicular seminomas. Here we investigated the expression of podoplanin in central nervous system (CNS) germ cell tumors (GCTs) by immunohistochemical staining of tumor samples from 62 patients. In 40 of 41 (98%) germinomas (including germinomatous components in mixed GCTs), podoplanin was diffusely expressed on the surface of germinoma cells; lymphocytes, interstitial cells, and syncytiotrophoblastic giant cells were negative for podoplanin. Except for immature teratomas (12/17; 71%), podoplanin expression was absent in non-germinomatous GCTs, including seven teratomas, seven embryonal carcinomas, seven yolk sac tumors, and seven choriocarcinomas. In immature teratomas, focal podoplanin staining was observed in fewer than 10% of immature squamous and columnar epithelial cells. Thus, podoplanin expression may be a sensitive immunohistochemical marker for germinoma in CNS GCTs. As such, it may be useful for diagnosis, for monitoring the efficacy of treatment, and as a potential target for antibody-based therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 14% |
| Student > Postgraduate | 3 | 14% |
| Student > Doctoral Student | 3 | 14% |
| Student > Bachelor | 2 | 10% |
| Researcher | 2 | 10% |
| Other | 5 | 24% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 33% |
| Biochemistry, Genetics and Molecular Biology | 3 | 14% |
| Agricultural and Biological Sciences | 3 | 14% |
| Veterinary Science and Veterinary Medicine | 2 | 10% |
| Neuroscience | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 5 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2012.
All research outputs
#4,696,560
of 22,789,076 outputs
Outputs from Acta Neuropathologica
#1,048
of 2,366 outputs
Outputs of similar age
#11,946
of 65,951 outputs
Outputs of similar age from Acta Neuropathologica
#4
of 14 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,366 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.