Title |
Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen
|
---|---|
Published in |
AAPS PharmSciTech, September 2007
|
DOI | 10.1208/pt0803076 |
Pubmed ID | |
Authors |
Carla Martins Lopes, José M. Sousa Lobo, João F. Pinto, Paulo C. Costa |
Abstract |
The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dual-component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (approximately 16 or >24 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 4 | 17% |
Student > Ph. D. Student | 3 | 13% |
Student > Master | 3 | 13% |
Other | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 17% |
Unknown | 7 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 13% |
Chemistry | 3 | 13% |
Agricultural and Biological Sciences | 1 | 4% |
Social Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 42% |