Title |
Prospective, Multicenter Study of Managing Lower Extremity Venous Ulcers
|
---|---|
Published in |
Annals of Vascular Surgery (Science Direct), July 1994
|
DOI | 10.1007/bf02132997 |
Pubmed ID | |
Authors |
Thomas E. Arnold, James C. Stanley, Elaine P. Fellows, Georgia A. Moncada, Roger Allen, Jerry J. Hutchinson, William M. Swartz, Laura L. Bolton, C.F.H. Vickers, Morris D. Kerstein |
Abstract |
Seventy patients with 90 venous ulcers were randomly assigned to hydrocolloid or conventional dressing and compression therapy at four study centers. The ulcers had been present for a mean of 47.8 in the control and 46.2 weeks in the treatment group and 42% of all patients had recurrent ulcers. Ulcers treated with hydrocolloid dressings reduced 71% and control treated wounds reduced 43% in area after 7.2 weeks of treatment. Thirty-four percent of all ulcers healed. Mean time to healing was 7 weeks for the hydrocolloid dressing group and 8 weeks for the control group. Most ulcers were less painful at final evaluation, but reduction in pain was more pronounced in hydrocolloid-dressed ulcers (p = 0.03). At baseline as well as during follow-up, significant differences between study centers were observed. Ulcers in patients in the United Kingdom were larger and less likely to heal (p = 0.001). Size of the ulcer at baseline was associated with treatment response and time to healing (p = 0.002). Percent reduction in ulcer area after 2 weeks was also correlated with treatment outcome (p = 0.004) and time to healing (p = 0.002). When all treatment outcome predictors were analyzed together, only percent reduction in area after 2 weeks remained statistically significant (p = 0.002), with percent reduction during the first 2 weeks of treatment > 30% predicting healing. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 16% |
Other | 4 | 13% |
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Student > Postgraduate | 3 | 10% |
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Other | 1 | 3% |
Unknown | 8 | 26% |