| Title |
Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis
|
|---|---|
| Published in |
Human Genetics, December 2006
|
| DOI | 10.1007/s00439-006-0293-z |
| Pubmed ID | |
| Authors |
Jeffrey S. Szeszko, Barry Healy, Helen Stevens, Yanina Balabanova, Francis Drobniewski, John A. Todd, Sergey Nejentsev |
| Abstract |
Recently, the Intracellular pathogen resistance 1 (Ipr1) gene was shown to control susceptibility to Mycobacterium tuberculosis in mice. We examined whether common sequence variants of its human orthologue, the SP110 gene, are associated with susceptibility to tuberculosis in a human population. We resequenced SP110 exons in 96 individuals and identified new polymorphisms. Then, we combined our sequence and HapMap data for 83 distinct polymorphisms and selected tags that capture information for all common variants in the 100 kb region around SP110. We genotyped 29 single nucleotide polymorphisms including seven amino-acid changing variants in 1,912 HIV-negative culture-confirmed adult pulmonary tuberculosis patients and 2,104 adult healthy controls from Russia and found no evidence of association. Our results indicate that common polymorphisms of the SP110 gene have no major effect on susceptibility to tuberculosis in this population. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 28 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 31% |
| Student > Ph. D. Student | 6 | 21% |
| Student > Master | 3 | 10% |
| Other | 2 | 7% |
| Student > Postgraduate | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 4 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 34% |
| Medicine and Dentistry | 7 | 24% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Immunology and Microbiology | 2 | 7% |
| Nursing and Health Professions | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 5 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Human Genetics
#933
of 2,953 outputs
Outputs of similar age
#41,525
of 155,913 outputs
Outputs of similar age from Human Genetics
#10
of 23 outputs
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