| Title |
Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes
|
|---|---|
| Published in |
Molecular Biology Reports, December 2011
|
| DOI | 10.1007/s11033-011-1372-3 |
| Pubmed ID | |
| Authors |
Han-Qiong Zhang, Xi-Feng Zhang, Lian-Jun Zhang, Hu-He Chao, Bo Pan, Yan-Min Feng, Lan Li, Xiao-Feng Sun, Wei Shen |
| Abstract |
Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. Frequent human exposure to this chemical has been proposed to be a potential public health risk. The objective of this study was to assess the effects of BPA on germ cell cyst breakdown and primordial follicle formation. Pregnant mice were treated with BPA at doses of 0, 0.02, 0.04, 0.08 mg/kg body weight/day from 12.5 day postcoitum. BPA was delivered orally to pregnant female mice. A dose-response relationship was observed with increased BPA exposure level associated with more oocytes in germ cell cyst and less primordial follicle at postnatal day 3 (P < 0.01). Progression to meiosis prophase I of oocytes was delayed in the 0.08 mg/kg bw/day treated group (P < 0.01). Decreased mRNA expression of specific meiotic genes including Stra8, Dmc1, Rec8 and Scp3 were observed. In conclusion, BPA exposure can affect the formation of primordial follicle by inhibiting meiotic progression of oocytes. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 75 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 28% |
| Student > Bachelor | 10 | 13% |
| Student > Master | 9 | 12% |
| Researcher | 6 | 8% |
| Student > Postgraduate | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 17% |
| Agricultural and Biological Sciences | 13 | 17% |
| Medicine and Dentistry | 9 | 12% |
| Environmental Science | 7 | 9% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 21 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2015.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Molecular Biology Reports
#389
of 2,907 outputs
Outputs of similar age
#70,582
of 243,385 outputs
Outputs of similar age from Molecular Biology Reports
#5
of 44 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,907 research outputs from this source. They receive a mean Attention Score of 2.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.