| Title |
Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells
|
|---|---|
| Published in |
Molecular Biology Reports, June 2012
|
| DOI | 10.1007/s11033-012-1716-7 |
| Pubmed ID | |
| Authors |
Xi-Feng Zhang, Lian-Jun Zhang, Yan-Ni Feng, Bo Chen, Yan-Min Feng, Gui-Jin Liang, Lan Li, Wei Shen |
| Abstract |
Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. Human frequent exposure to this chemical has been proposed to be a potential public health risk. The objective of this study was to assess the effects of BPA on DNA methylation of imprinting genes in fetal mouse germ cell. Pregnant mice were treated with BPA at doses of 0, 40, 80 and 160 μg BPA/kg body weight/day from 0.5 day post coitum. DNA methylation of imprinting genes, Igf2r, Peg3 and H19, was decreased with the increase of BPA concentration in fetal mouse germ cells (p < 0.01).The relative mRNA levels of Nobox were lower in BPA-treated group compared to control (BPA free) in female fetal germ cells, but in male fetal germ cells, a significant higher in Nobox expression was observed in BPA-treated group compared to control. Decreased mRNA expression of specific meiotic genes including Stimulated by Stra8 and Dazl were obtained in the female fetal germ cells. In conclusion, BPA exposure can affect the DNA methylation of imprinting genes in fetal mouse germ cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Netherlands | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 24% |
| Researcher | 12 | 21% |
| Student > Bachelor | 6 | 10% |
| Student > Master | 5 | 9% |
| Student > Doctoral Student | 3 | 5% |
| Other | 10 | 17% |
| Unknown | 8 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 17% |
| Agricultural and Biological Sciences | 9 | 16% |
| Environmental Science | 7 | 12% |
| Medicine and Dentistry | 6 | 10% |
| Neuroscience | 4 | 7% |
| Other | 8 | 14% |
| Unknown | 14 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2015.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Molecular Biology Reports
#389
of 2,907 outputs
Outputs of similar age
#54,910
of 166,238 outputs
Outputs of similar age from Molecular Biology Reports
#8
of 52 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,907 research outputs from this source. They receive a mean Attention Score of 2.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.