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Mendeley readers
Attention Score in Context
| Title |
Metabolic engineering of microorganisms: general strategies and drug production
|
|---|---|
| Published in |
Drug Discovery Today, January 2009
|
| DOI | 10.1016/j.drudis.2008.08.004 |
| Pubmed ID | |
| Authors |
Sang Yup Lee, Hyun Uk Kim, Jin Hwan Park, Jong Myung Park, Tae Yong Kim |
| Abstract |
Rac is a protein involved in the various functions of macrophages (Mphi), including the production of reactive oxygen species (ROS), phagocytosis, chemotaxis and the secretion of cytokines (such as gamma-INF). This study tested the effects of nucleosides containing 8-oxoguanine(8-hydroxyguanine) such as 8-oxo-2'-guanosine (8-oxoG) or 8-oxo-2'-deoxyguanosine (8-oxodG), on Rac and the above-listed Rac-associated functions of Mphi using mouse peritoneal Mphi (MpMphi). It is reported that 8-oxodG was able to effectively inhibit Rac and the Rac-associated functions of MpMphi. Compared to 8-oxodG, 8-oxoG showed negligible effects. Furthermore, normal nucleosides such as deoxyguanosine (dG), guanosine (G) and adenosine (A) did not exert any effects. These results suggest that 8-oxodG could be used as a potential tool to modulate the functions of Mphi that are intimately related to various pathological processes. |
Mendeley readers
The data shown below were compiled from readership statistics for 363 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Germany | 3 | <1% |
| Denmark | 3 | <1% |
| Brazil | 3 | <1% |
| Austria | 2 | <1% |
| Netherlands | 2 | <1% |
| South Africa | 1 | <1% |
| India | 1 | <1% |
| Chile | 1 | <1% |
| Other | 8 | 2% |
| Unknown | 333 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 91 | 25% |
| Researcher | 66 | 18% |
| Student > Master | 44 | 12% |
| Student > Bachelor | 34 | 9% |
| Professor > Associate Professor | 23 | 6% |
| Other | 69 | 19% |
| Unknown | 36 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 183 | 50% |
| Biochemistry, Genetics and Molecular Biology | 52 | 14% |
| Engineering | 21 | 6% |
| Chemistry | 21 | 6% |
| Chemical Engineering | 9 | 2% |
| Other | 37 | 10% |
| Unknown | 40 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#4,803,389
of 23,202,641 outputs
Outputs from Drug Discovery Today
#753
of 2,619 outputs
Outputs of similar age
#26,693
of 170,745 outputs
Outputs of similar age from Drug Discovery Today
#6
of 20 outputs
Altmetric has tracked 23,202,641 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,619 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.