Title |
HPV6b virus like particles are potent immunogens without adjuvant in man
|
---|---|
Published in |
Vaccine, January 2000
|
DOI | 10.1016/s0264-410x(99)00351-5 |
Pubmed ID | |
Authors |
Li Fang Zhang, Jian Zhou, Shao Chen, Lian Lian Cai, Qi Yu Bao, Fei Yun Zheng, Jie Qiang Lu, Jagadish Padmanabha, Kylie Hengst, Karen Malcolm, Ian H Frazer |
Abstract |
Subjects with genital warts were immunized three times or more with HPV6b VLPs without adjuvant. All immunized subjects had DTH to HPV6b L1 protein. Of 32 subjects, nine had HPV6b specific antibody prior to immunization and 22 acquired antibody with immunization. VLP specific antibody increased following a single immunization in 6 of 8 subjects with low level antibody at recruitment. Complete regression of genital warts was observed in 25 of 33 evaluable subjects over the 20-week observation period. We conclude that immunization with HPV6b L1 VLPs without adjuvant induces immunity to the L1 protein epitopes recognised during natural infection, and may accelerate regression of warts. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Unknown | 54 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 20% |
Student > Ph. D. Student | 9 | 16% |
Student > Bachelor | 6 | 11% |
Student > Master | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 15% |
Unknown | 12 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 24% |
Medicine and Dentistry | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Chemistry | 3 | 5% |
Other | 5 | 9% |
Unknown | 18 | 33% |