| Title |
The Role of Matrix Composition in the Mechanical Behavior of Bone
|
|---|---|
| Published in |
Current Osteoporosis Reports, April 2018
|
| DOI | 10.1007/s11914-018-0433-0 |
| Pubmed ID | |
| Authors |
Mustafa Unal, Amy Creecy, Jeffry S. Nyman |
| Abstract |
While thinning of the cortices or trabeculae weakens bone, age-related changes in matrix composition also lower fracture resistance. This review summarizes how the organic matrix, mineral phase, and water compartments influence the mechanical behavior of bone, thereby identifying characteristics important to fracture risk. In the synthesis of the organic matrix, tropocollagen experiences various post-translational modifications that facilitate a highly organized fibril of collagen I with a preferred orientation giving bone extensibility and several toughening mechanisms. Being a ceramic, mineral is brittle but increases the strength of bone as its content within the organic matrix increases. With time, hydroxyapatite-like crystals experience carbonate substitutions, the consequence of which remains to be understood. Water participates in hydrogen bonding with organic matrix and in electrostatic attractions with mineral phase, thereby providing stability to collagen-mineral interface and ductility to bone. Clinical tools sensitive to age- and disease-related changes in matrix composition that the affect mechanical behavior of bone could potentially improve fracture risk assessment. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 170 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 21% |
| Researcher | 21 | 12% |
| Student > Master | 21 | 12% |
| Student > Bachelor | 11 | 6% |
| Student > Doctoral Student | 8 | 5% |
| Other | 21 | 12% |
| Unknown | 52 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 25 | 15% |
| Medicine and Dentistry | 19 | 11% |
| Materials Science | 17 | 10% |
| Biochemistry, Genetics and Molecular Biology | 9 | 5% |
| Agricultural and Biological Sciences | 6 | 4% |
| Other | 24 | 14% |
| Unknown | 70 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2018.
All research outputs
#14,382,892
of 23,033,713 outputs
Outputs from Current Osteoporosis Reports
#274
of 550 outputs
Outputs of similar age
#186,819
of 329,108 outputs
Outputs of similar age from Current Osteoporosis Reports
#5
of 21 outputs
Altmetric has tracked 23,033,713 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 550 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,108 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.