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Mendeley readers
Attention Score in Context
| Title |
LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation
|
|---|---|
| Published in |
EMBO Journal, July 2004
|
| DOI | 10.1038/sj.emboj.7600342 |
| Pubmed ID | |
| Authors |
Gal Gur, Chanan Rubin, Menachem Katz, Ido Amit, Ami Citri, Jonas Nilsson, Ninette Amariglio, Roger Henriksson, Gideon Rechavi, Håkan Hedman, Ron Wides, Yosef Yarden |
| Abstract |
Kekkon proteins negatively regulate the epidermal growth factor receptor (EGFR) during oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane protein whose inactivation in rodents promotes skin hyperplasia, suggesting involvement in EGFR regulation. We report upregulation of LRIG1 transcript and protein upon EGF stimulation, and physical association of the encoded protein with the four EGFR orthologs of mammals. Upregulation of LRIG1 is followed by enhanced ubiquitylation and degradation of EGFR. The underlying mechanism involves recruitment of c-Cbl, an E3 ubiquitin ligase that simultaneously ubiquitylates EGFR and LRIG1 and sorts them for degradation. We conclude that LRIG1 evolved in mammals as a feedback negative attenuator of signaling by receptor tyrosine kinases. |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Netherlands | 1 | 1% |
| Sweden | 1 | 1% |
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 93 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 22% |
| Researcher | 16 | 16% |
| Student > Master | 15 | 15% |
| Student > Bachelor | 9 | 9% |
| Professor | 8 | 8% |
| Other | 22 | 22% |
| Unknown | 7 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 44% |
| Biochemistry, Genetics and Molecular Biology | 24 | 24% |
| Neuroscience | 6 | 6% |
| Medicine and Dentistry | 6 | 6% |
| Immunology and Microbiology | 4 | 4% |
| Other | 3 | 3% |
| Unknown | 12 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2019.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from EMBO Journal
#3,834
of 12,110 outputs
Outputs of similar age
#10,807
of 59,690 outputs
Outputs of similar age from EMBO Journal
#19
of 77 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,110 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,690 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.