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Troyer Syndrome Protein Spartin Is Mono-Ubiquitinated and Functions in EGF Receptor Trafficking

Overview of attention for article published in Molecular Biology of the Cell, March 2007
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Title
Troyer Syndrome Protein Spartin Is Mono-Ubiquitinated and Functions in EGF Receptor Trafficking
Published in
Molecular Biology of the Cell, March 2007
DOI 10.1091/mbc.e06-09-0833
Pubmed ID
Authors

Joanna C. Bakowska, Henri Jupille, Parvin Fatheddin, Rosa Puertollano, Craig Blackstone

Abstract

Troyer syndrome is an autosomal recessive hereditary spastic paraplegia caused by mutation in the spartin (SPG20) gene, which encodes a widely expressed protein of unknown function. This mutation results in premature protein truncation and thus might signify a loss-of-function disease mechanism. In this study, we have found that spartin is mono-ubiquitinated and functions in degradation of the epidermal growth factor receptor (EGFR). Upon EGF stimulation, spartin translocates from the cytoplasm to the plasma membrane and colocalizes with internalized EGF-Alexa. Knockdown of spartin by small interfering RNA decreases the rate of EGFR degradation and also affects EGFR internalization, recycling, or both. Furthermore, overexpression of spartin results in a prominent decrease in EGFR degradation. Taken together, our data suggest that spartin is involved in the intracellular trafficking of EGFR and that impaired endocytosis may underlie the pathogenesis of Troyer syndrome.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
France 1 2%
Unknown 53 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 18%
Student > Ph. D. Student 9 16%
Student > Master 6 11%
Researcher 5 9%
Student > Doctoral Student 4 7%
Other 11 20%
Unknown 10 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 36%
Biochemistry, Genetics and Molecular Biology 11 20%
Neuroscience 6 11%
Medicine and Dentistry 5 9%
Social Sciences 1 2%
Other 2 4%
Unknown 10 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2022.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Molecular Biology of the Cell
#2,057
of 5,478 outputs
Outputs of similar age
#32,444
of 90,358 outputs
Outputs of similar age from Molecular Biology of the Cell
#19
of 50 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,478 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,358 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.