↓ Skip to main content

Portrait of a canine probiotic Bifidobacterium—From gut to gut

Overview of attention for article published in Veterinary Microbiology, May 2009
Altmetric Badge

Mentioned by

patent
1 patent

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
86 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Portrait of a canine probiotic Bifidobacterium—From gut to gut
Published in
Veterinary Microbiology, May 2009
DOI 10.1016/j.vetmic.2009.05.002
Pubmed ID
Authors

D. O’Mahony, K. Barry Murphy, J. MacSharry, T. Boileau, G. Sunvold, G. Reinhart, B. Kiely, F. Shanahan, L. O’Mahony

Abstract

The gastrointestinal environment is a complex interactive system involving the host, ingested dietary components, and numerous microbial species. We hypothesized that isolation and screening of Lactobacilli and Bifidobacteria adherent to healthy canine gastrointestinal tissue would yield strains with commensal activity in canines. The aims of this study were (1) to isolate a bank of commensal organisms from the canine gastrointestinal tract; (2) to screen these novel microbial isolates for potential probiotic effects; (3) to select one organism from these screens and test its impact on the canine microbiota. Lactic acid bacteria (LAB) were isolated from resected canine gastrointestinal tissue and screened in vitro for putative probiotic activities. Murine studies examined gastrointestinal transit and inhibition of Salmonella typhimurium translocation. One strain was progressed to a canine study where its impact on the gastrointestinal microbiota was determined. Of the 420 isolates from the canine gut, 62 strains were characterised as LAB. Following assessment of the strain bank with regard to pH sensitivity, bile resistance, pathogen inhibition and survival following freeze-drying, four Lactobacillus strains and two Bifidobacteria strains were selected for further examination. Bifidobacterium animalis AHC7 adhered to epithelial cells, transited the murine gastrointestinal tract to high numbers and significantly reduced S. typhimurium translocation. B. animalis AHC7 consumption significantly reduced the carriage of Clostridia, in particular Clostridium difficile, in dogs. This study describes the isolation and screening of canine-derived bacterial strains with commensal traits. The results demonstrate that B. animalis AHC7 has significant potential for improving canine gastrointestinal health.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
France 1 1%
Ireland 1 1%
Uruguay 1 1%
New Zealand 1 1%
Peru 1 1%
United States 1 1%
Unknown 78 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 16%
Student > Master 12 14%
Student > Bachelor 7 8%
Student > Ph. D. Student 6 7%
Other 6 7%
Other 22 26%
Unknown 19 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 35%
Medicine and Dentistry 12 14%
Veterinary Science and Veterinary Medicine 8 9%
Immunology and Microbiology 7 8%
Unspecified 2 2%
Other 6 7%
Unknown 21 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2014.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from Veterinary Microbiology
#946
of 3,793 outputs
Outputs of similar age
#37,920
of 107,171 outputs
Outputs of similar age from Veterinary Microbiology
#10
of 27 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,793 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,171 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.