| Title |
Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, June 2008
|
| DOI | 10.1007/s00018-008-8148-5 |
| Pubmed ID | |
| Authors |
K. Hochrainer, R. Kroismayr, U. Baranyi, B. R. Binder, J. Lipp |
| Abstract |
Small HERC proteins are defined by the presence of one RCC1-like domain and a HECT domain. Having evolved out of one common ancestor, the four members of the family exhibit a high degree of homology in genomic organization and amino acid sequence, thus it seems possible that they might accomplish similar functions. Here we show that small HERC proteins interact with each other and localize to the same cellular structures, which we identify as late endosomes and lysosomes. We demonstrate interaction of HERC3 with the ubiquitin-like proteins hPLIC-1 and hPLIC-2 and we establish interaction of HERC5 with the metastasis suppressor Nm23B. While hPLIC proteins are not ubiquitinated by HERC3, HERC5 plays an important role in ubiquitination of Nm23B. In summary, although small HERC proteins are highly homologous showing the same subcellular distribution, they undergo different molecular interactions. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Netherlands | 1 | 3% |
| Unknown | 38 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 23% |
| Student > Bachelor | 5 | 13% |
| Researcher | 5 | 13% |
| Student > Master | 5 | 13% |
| Professor > Associate Professor | 4 | 10% |
| Other | 7 | 18% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 40% |
| Biochemistry, Genetics and Molecular Biology | 9 | 23% |
| Medicine and Dentistry | 6 | 15% |
| Immunology and Microbiology | 2 | 5% |
| Unknown | 7 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2015.
All research outputs
#7,845,540
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,655
of 4,151 outputs
Outputs of similar age
#29,444
of 83,869 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#13
of 30 outputs
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