| Title |
Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited
|
|---|---|
| Published in |
BMC Cancer, January 2006
|
| DOI | 10.1186/1471-2407-6-20 |
| Pubmed ID | |
| Authors |
Michaël Gué, Jian-Sheng Sun, Thomas Boudier |
| Abstract |
Haematological cancer is characterised by chromosomal translocation (e.g. MLL translocation in acute leukaemia) and two models have been proposed to explain the origins of recurrent reciprocal translocation. The first, established from pairs of translocated genes (such as BCR and ABL), considers the spatial proximity of loci in interphase nuclei (static "contact first" model). The second model is based on the dynamics of double strand break ends during repair processes (dynamic "breakage first" model). Since the MLL gene involved in 11q23 translocation has more than 40 partners, the study of the relative positions of the MLL gene with both the most frequent partner gene (AF4) and a less frequent partner gene (ENL), should elucidate the MLL translocation mechanism. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Netherlands | 1 | 2% |
| Belarus | 1 | 2% |
| Unknown | 41 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 36% |
| Other | 5 | 11% |
| Student > Ph. D. Student | 5 | 11% |
| Student > Bachelor | 3 | 7% |
| Professor | 3 | 7% |
| Other | 6 | 13% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 40% |
| Biochemistry, Genetics and Molecular Biology | 10 | 22% |
| Medicine and Dentistry | 8 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Arts and Humanities | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 5 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from BMC Cancer
#2,059
of 8,294 outputs
Outputs of similar age
#40,662
of 154,763 outputs
Outputs of similar age from BMC Cancer
#6
of 15 outputs
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