| Title |
Discovery of PACAP and its receptors in the brain
|
|---|---|
| Published in |
The Journal of Headache and Pain, April 2018
|
| DOI | 10.1186/s10194-018-0855-1 |
| Pubmed ID | |
| Authors |
Takahiro Hirabayashi, Tomoya Nakamachi, Seiji Shioda |
| Abstract |
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP. Because of the high homology of the amino acid sequences of PACAP and VIP, these peptides share three class B-G-protein coupled receptors: the PAC1-Receptor (PAC1-R), the VPAC1-Receptor (VPAC1-R) and VPAC2-Receptor (VPAC2-R). These receptors have high homology to each other, and their high homology is utilized for these discoveries. This review provides mainly an overview of the history of the discovery of PACAP and its three receptors. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 98 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 16% |
| Researcher | 14 | 14% |
| Student > Master | 12 | 12% |
| Student > Bachelor | 10 | 10% |
| Unspecified | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 25 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 15% |
| Biochemistry, Genetics and Molecular Biology | 15 | 15% |
| Medicine and Dentistry | 12 | 12% |
| Agricultural and Biological Sciences | 10 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 13 | 13% |
| Unknown | 28 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2018.
All research outputs
#19,244,099
of 23,849,058 outputs
Outputs from The Journal of Headache and Pain
#1,210
of 1,417 outputs
Outputs of similar age
#258,317
of 331,096 outputs
Outputs of similar age from The Journal of Headache and Pain
#15
of 19 outputs
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So far Altmetric has tracked 1,417 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.6. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.