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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish
|
|---|---|
| Published in |
FASEB Journal, February 2015
|
| DOI | 10.1096/fj.14-265090 |
| Pubmed ID | |
| Authors |
Jessie Jeffery, Christine Neyt, Wade Moore, Scott Paterson, Neil I. Bower, Georgia Chenevix‐Trench, Heather Verkade, Benjamin M. Hogan, Kum Kum Khanna |
| Abstract |
CEP55 was initially described as a centrosome- and midbody-associated protein and a key mediator of cytokinesis. More recently, it has been implicated in PI3K/AKT pathway activation via an interaction with the catalytic subunit of PI3K. However, its role in embryonic development is unknown. Here we describe a cep55 nonsense mutant zebrafish with which we can study the in vivo physiologic role of Cep55. Homozygous mutants underwent extensive apoptosis by 24 hours postfertilization (hpf) concomitant with cell cycle defects, and heterozygous carriers were indistinguishable from their wild-type siblings. A similar phenotype was also observed in zebrafish injected with a cep55 morpholino, suggesting the mutant is a cep55 loss-of-function model. Further analysis revealed that Akt was destabilized in the homozygous mutants, which partially phenocopied Akt1 and Akt2 knockdown. Expression of either constitutively activated PIK3CA or AKT1 could partially rescue the homozygous mutants. Consistent with a role for Cep55 in regulation of Akt stability, treatment with proteasome inhibitor, MG132, partially rescued the homozygous mutants. Taken together, these results provide the first description of Cep55 in development and underline the importance of Cep55 in the regulation of Pi3k/Akt pathway and in particular Akt stability.-Jeffery, J., Neyt, C., Moore, W., Paterson, S., Bower, N. I., Chenevix-Trench, G., Verkade, H., Hogan, B. M., Khanna, K. K. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 20% |
| Student > Ph. D. Student | 5 | 20% |
| Student > Master | 4 | 16% |
| Researcher | 3 | 12% |
| Student > Doctoral Student | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 36% |
| Agricultural and Biological Sciences | 7 | 28% |
| Medicine and Dentistry | 3 | 12% |
| Unknown | 6 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2015.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from FASEB Journal
#7,584
of 11,448 outputs
Outputs of similar age
#224,626
of 364,730 outputs
Outputs of similar age from FASEB Journal
#68
of 104 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,448 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,730 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.