Title |
Elevated Serotonin Transporter Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]DASB; Comparison with Bipolar Disorder
|
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Published in |
Biological Psychiatry, August 2007
|
DOI | 10.1016/j.biopsych.2007.03.016 |
Pubmed ID | |
Authors |
Dara M. Cannon, Masanori Ichise, Denise Rollis, Jacqueline M. Klaver, Shilpa K. Gandhi, Dennis S. Charney, Husseini K. Manji, Wayne C. Drevets |
Abstract |
Altered serotonergic function is thought to play a role in the pathophysiology of major depressive episodes based upon evidence from neuroimaging, pharmacological, postmortem and genetic studies. It remains unclear, however, whether depressed samples that differ with respect to having shown a unipolar versus a bipolar illness course also would show distinct patterns of abnormalities within the serotonergic system. The current study compared serotonin transporter (5-HTT) binding between unipolar-depressives (MDD), bipolar-depressives (BD) and healthy-controls (HC) to assess whether the abnormalities in 5-HTT binding recently found in depressed subjects with BD extend to depressed subjects with MDD. |
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Other | 0 | 0% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 26 | 20% |
Student > Master | 18 | 14% |
Student > Ph. D. Student | 16 | 12% |
Professor > Associate Professor | 14 | 11% |
Student > Doctoral Student | 12 | 9% |
Other | 29 | 22% |
Unknown | 16 | 12% |
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Neuroscience | 24 | 18% |
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Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 14 | 11% |
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