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Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD

Overview of attention for article published in Molecular Psychiatry, June 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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1 patent
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1 Wikipedia page

Citations

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109 Dimensions

Readers on

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87 Mendeley
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Title
Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD
Published in
Molecular Psychiatry, June 2005
DOI 10.1038/sj.mp.4001698
Pubmed ID
Authors

K Sheehan, N Lowe, A Kirley, C Mullins, M Fitzgerald, M Gill, Z Hawi

Abstract

Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally, the TPH gene was thought to be widely expressed, but a second form of TPH, TPH2, was recently identified and the TPH2 gene was found to be solely expressed in the brain. We examined eight single nucleotide polymorphisms (SNP) in the TPH2 gene for association with ADHD in 179 Irish nuclear families. Transmission disequilibrium test analysis revealed significant association between the T allele of marker rs1843809 with the disorder (chi2=12.2, P=0.0006, OR=2.36). Stratifying data by the sex of the transmitting parent showed that this association was enhanced when paternal transmission was considered (OR=3.7). In addition, several haplotypes (all including the associated marker) were associated with ADHD. These preliminary findings suggest that TPH2 is a susceptibility locus for ADHD. Further confirmation, preferably from different ethnic groups, is required to firmly implicate TPH2 in the pathophysiology of ADHD.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
United States 1 1%
Australia 1 1%
Canada 1 1%
Unknown 83 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 17%
Researcher 13 15%
Student > Master 9 10%
Student > Bachelor 9 10%
Student > Postgraduate 6 7%
Other 21 24%
Unknown 14 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 23%
Psychology 15 17%
Medicine and Dentistry 14 16%
Biochemistry, Genetics and Molecular Biology 7 8%
Neuroscience 5 6%
Other 8 9%
Unknown 18 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2023.
All research outputs
#5,595,291
of 23,524,722 outputs
Outputs from Molecular Psychiatry
#2,419
of 4,226 outputs
Outputs of similar age
#10,653
of 57,743 outputs
Outputs of similar age from Molecular Psychiatry
#4
of 18 outputs
Altmetric has tracked 23,524,722 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,226 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.3. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.