| Title |
Focus on phosphohistidine
|
|---|---|
| Published in |
Amino Acids, November 2006
|
| DOI | 10.1007/s00726-006-0443-6 |
| Pubmed ID | |
| Authors |
P. V. Attwood, M. J. Piggott, X. L. Zu, P. G. Besant |
| Abstract |
Phosphohistidine has been identified as an enzymic intermediate in numerous biochemical reactions and plays a functional role in many regulatory pathways. Unlike the phosphoester bond of its cousins (phosphoserine, phosphothreonine and phosphotyrosine), the phosphoramidate (P-N) bond of phosphohistidine has a high DeltaG degrees of hydrolysis and is unstable under acidic conditions. This acid-lability has meant that the study of protein histidine phosphorylation and the associated protein kinases has been slower to progress than other protein phosphorylation studies. Histidine phosphorylation is a crucial component of cell signalling in prokaryotes and lower eukaryotes. It is also now becoming widely reported in mammalian signalling pathways and implicated in certain human disease states. This review covers the chemistry of phosphohistidine in terms of its isomeric forms and chemical derivatives, how they can be synthesized, purified, identified and the relative stabilities of each of these forms. Furthermore, we highlight how this chemistry relates to the role of phosphohistidine in its various biological functions. |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 3% |
| United States | 2 | 1% |
| Germany | 1 | <1% |
| India | 1 | <1% |
| Belgium | 1 | <1% |
| Portugal | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 134 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 26% |
| Researcher | 25 | 17% |
| Student > Master | 24 | 16% |
| Student > Bachelor | 19 | 13% |
| Professor > Associate Professor | 7 | 5% |
| Other | 13 | 9% |
| Unknown | 20 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 51 | 35% |
| Agricultural and Biological Sciences | 29 | 20% |
| Biochemistry, Genetics and Molecular Biology | 29 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Immunology and Microbiology | 3 | 2% |
| Other | 9 | 6% |
| Unknown | 21 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2017.
All research outputs
#4,696,560
of 22,789,076 outputs
Outputs from Amino Acids
#288
of 1,518 outputs
Outputs of similar age
#12,389
of 68,184 outputs
Outputs of similar age from Amino Acids
#5
of 13 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,518 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,184 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.