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Mendeley readers
Attention Score in Context
| Title |
The SH-3 and SH-4 Antibodies Recognize Distinct Epitopes on CD73 from Human Mesenchymal Stem Cells
|
|---|---|
| Published in |
Biochemical & Biophysical Research Communications, November 2001
|
| DOI | 10.1006/bbrc.2001.6013 |
| Pubmed ID | |
| Authors |
F Barry, R Boynton, M Murphy, S Haynesworth, J Zaia |
| Abstract |
Mesenchymal stem cells (MSCs) are pluripotent cells in the bone marrow that have the capacity to differentiate along a number of connective tissue lineages, including cartilage, bone, adipose tissue, and stroma. The SH-3 and SH-4 monoclonal antibodies recognize epitopes present on the surface of human MSCs. This study describes the isolation and characterization of the antigen that is recognized by these antibodies. A protein of molecular weight approximately 67 kDa was immunoprecipitated from a solubilized membrane preparation of human MSCs using the SH-3 antibody. Analysis of peptides derived from this protein by mass spectrometry and sequencing identified it as CD73 (ecto-5'-nucleotidase). The SH-4 antibody was also shown to react with purified bovine CD73 by immunoblotting, but the SH-3 antibody failed to react with the bovine protein. These results indicate that both SH-3 and SH-4 epitopes are present on CD73, but they are distinct. CD73, present in lymphoid tissue, plays a role in the activation of B-lymphocytes and in signal transduction in the hematopoietic compartment of bone marrow. The role that CD73 may play in bone marrow stromal interactions and in the differentiation of MSCs is discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| United Kingdom | 2 | 2% |
| Czechia | 1 | <1% |
| Japan | 1 | <1% |
| France | 1 | <1% |
| Unknown | 99 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 23% |
| Student > Ph. D. Student | 21 | 20% |
| Student > Bachelor | 13 | 12% |
| Student > Doctoral Student | 9 | 8% |
| Professor | 9 | 8% |
| Other | 24 | 22% |
| Unknown | 6 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 40% |
| Medicine and Dentistry | 21 | 20% |
| Biochemistry, Genetics and Molecular Biology | 19 | 18% |
| Engineering | 4 | 4% |
| Veterinary Science and Veterinary Medicine | 3 | 3% |
| Other | 4 | 4% |
| Unknown | 13 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2023.
All research outputs
#2,863,997
of 25,374,917 outputs
Outputs from Biochemical & Biophysical Research Communications
#545
of 26,637 outputs
Outputs of similar age
#2,885
of 45,941 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#3
of 159 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,637 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 45,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 159 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.