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Mendeley readers
Attention Score in Context
| Title |
Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella
|
|---|---|
| Published in |
EMBO Journal, March 2010
|
| DOI | 10.1038/emboj.2010.28 |
| Pubmed ID | |
| Authors |
Markus C Kerr, Jack T H Wang, Natalie A Castro, Nicholas A Hamilton, Liam Town, Darren L Brown, Frederic A Meunier, Nat F Brown, Jennifer L Stow, Rohan D Teasdale |
| Abstract |
3-phosphorylated phosphoinositides (3-PtdIns) orchestrate endocytic trafficking pathways exploited by intracellular pathogens such as Salmonella to gain entry into the cell. To infect the host, Salmonellae subvert its normal macropinocytic activity, manipulating the process to generate an intracellular replicative niche. Disruption of the PtdIns(5) kinase, PIKfyve, be it by interfering mutant, siRNA-mediated knockdown or pharmacological means, inhibits the intracellular replication of Salmonella enterica serovar typhimurium in epithelial cells. Monitoring the dynamics of macropinocytosis by time-lapse 3D (4D) videomicroscopy revealed a new and essential role for PI(3,5)P(2) in macropinosome-late endosome/lysosome fusion, which is distinct from that of the small GTPase Rab7. This PI(3,5)P(2)-dependent step is required for the proper maturation of the Salmonella-containing vacuole (SCV) through the formation of Salmonella-induced filaments (SIFs) and for the engagement of the Salmonella pathogenicity island 2-encoded type 3 secretion system (SPI2-T3SS). Finally, although inhibition of PIKfyve in macrophages did inhibit Salmonella replication, it also appears to disrupt the macrophage's bactericidal response. |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 3 | 3% |
| Germany | 1 | <1% |
| Portugal | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 99 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 23% |
| Researcher | 22 | 21% |
| Student > Master | 10 | 9% |
| Professor > Associate Professor | 8 | 8% |
| Student > Bachelor | 7 | 7% |
| Other | 20 | 19% |
| Unknown | 15 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 42% |
| Immunology and Microbiology | 12 | 11% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Medicine and Dentistry | 6 | 6% |
| Chemistry | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 20 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2024.
All research outputs
#3,802,284
of 25,394,764 outputs
Outputs from EMBO Journal
#2,355
of 12,116 outputs
Outputs of similar age
#15,668
of 110,221 outputs
Outputs of similar age from EMBO Journal
#7
of 41 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,116 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.