| Title |
Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment
|
|---|---|
| Published in |
Environmental Health, February 2015
|
| DOI | 10.1186/1476-069x-14-13 |
| Pubmed ID | |
| Authors |
Fabien Lagarde, Claire Beausoleil, Scott M Belcher, Luc P Belzunces, Claude Emond, Michel Guerbet, Christophe Rousselle |
| Abstract |
Experimental studies investigating the effects of endocrine disruptors frequently identify potential unconventional dose-response relationships called non-monotonic dose-response (NMDR) relationships. Standardized approaches for investigating NMDR relationships in a risk assessment context are missing. The aim of this work was to develop criteria for assessing the strength of NMDR relationships. A literature search was conducted to identify published studies that report NMDR relationships with endocrine disruptors. Fifty-one experimental studies that investigated various effects associated with endocrine disruption elicited by many substances were selected. Scoring criteria were applied by adaptation of an approach previously used for identification of hormesis-type dose-response relationships. Out of the 148 NMDR relationships analyzed, 82 were categorized with this method as having a "moderate" to "high" level of plausibility for various effects. Numerous modes of action described in the literature can explain such phenomena. NMDR can arise from numerous molecular mechanisms such as opposing effects induced by multiple receptors differing by their affinity, receptor desensitization, negative feedback with increasing dose, or dose-dependent metabolism modulation. A stepwise decision tree was developed as a tool to standardize the analysis of NMDR relationships observed in the literature with the final aim to use these results in a Risk Assessment purpose. This decision tree was finally applied to studies focused on the effects of bisphenol A. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 11% |
| United States | 1 | 11% |
| Unknown | 7 | 78% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 339 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | <1% |
| France | 3 | <1% |
| United States | 2 | <1% |
| South Africa | 1 | <1% |
| Chile | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 327 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 72 | 21% |
| Student > Master | 50 | 15% |
| Researcher | 39 | 12% |
| Student > Bachelor | 23 | 7% |
| Student > Doctoral Student | 21 | 6% |
| Other | 53 | 16% |
| Unknown | 81 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 16% |
| Biochemistry, Genetics and Molecular Biology | 39 | 12% |
| Environmental Science | 39 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 27 | 8% |
| Medicine and Dentistry | 27 | 8% |
| Other | 51 | 15% |
| Unknown | 103 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#553,390
of 25,382,250 outputs
Outputs from Environmental Health
#156
of 1,601 outputs
Outputs of similar age
#7,291
of 369,052 outputs
Outputs of similar age from Environmental Health
#4
of 27 outputs
Altmetric has tracked 25,382,250 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,601 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.9. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.