| Title |
Nascent-polypeptide-associated complex
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2002
|
| DOI | 10.1007/pl00012490 |
| Pubmed ID | |
| Authors |
S. Rospert, Y. Dubaquié, M. Gautschi |
| Abstract |
Nascent-polypeptide-associated complex (NAC) is a heterodimeric complex which can reversibly bind to eukaryotic ribosomes. NAC is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. Although its function is thought to be conserved from yeast to humans our current knowledge about what NAC actually does in a living cell is incomplete. It has been suggested that NAC is a (i) dynamic component of the ribosomal exit tunnel, providing a shield for nascent polypeptides, (ii) negative regulator of translocation into the endoplasmic reticulum and (iii) positive regulator of translocation into the mitochondria. However, none of these hypotheses is generally accepted. Moreover, the individual subunits of NAC have been implicated in processes related to transcription rather than translation, and it is currently under debate whether NAC might be a protein of dual function. This review attempts to summarize the data from different fields and to discuss the partly controversial results in a common context. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 84 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 28% |
| Student > Master | 16 | 19% |
| Researcher | 13 | 15% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 3 | 3% |
| Other | 4 | 5% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 45% |
| Biochemistry, Genetics and Molecular Biology | 24 | 28% |
| Chemistry | 3 | 3% |
| Physics and Astronomy | 1 | 1% |
| Computer Science | 1 | 1% |
| Other | 0 | 0% |
| Unknown | 18 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2022.
All research outputs
#2,319,446
of 25,374,917 outputs
Outputs from Cellular and Molecular Life Sciences
#293
of 5,877 outputs
Outputs of similar age
#2,470
of 49,679 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#1
of 17 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,877 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 49,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.