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Mendeley readers
Attention Score in Context
| Title |
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling
|
|---|---|
| Published in |
Cellular Signalling, January 2007
|
| DOI | 10.1016/j.cellsig.2007.01.013 |
| Pubmed ID | |
| Authors |
Wayne A. Schroder, Marion Buck, Nicole Cloonan, John F. Hancock, Andreas Suhrbier, Tom Sculley, Gillian Bushell |
| Abstract |
Human Sin1 (SAPK-interacting protein 1) is a member of a conserved family of orthologous proteins that have an essential role in signal transduction in yeast and Dictyostelium. This study demonstrates that most Sin1 orthologues contain both a Raf-like Ras-binding domain (RBD) and a pleckstrin homology (PH) domain. These domains are functional in the human Sin1 protein, with the PH domain involved in lipid and membrane binding by Sin1, and the RBD able to bind activated H-and K-Ras. Sin1 and Ras co-immunoprecipitated and co-localised, showing that these proteins associate with each other in vivo. Overexpression of Sin1 inhibited the activation of ERK, Akt and JNK signalling pathways by Ras. In contrast, siRNA knockdown of endogenous Sin1 protein expression in HEK293 cells enhanced the activation of ERK1/2 by Ras. These data suggest that Sin1 is a mammalian Ras-inhibitor. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Japan | 1 | 1% |
| France | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 71 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 32% |
| Researcher | 17 | 22% |
| Student > Master | 9 | 12% |
| Professor > Associate Professor | 4 | 5% |
| Student > Bachelor | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 41% |
| Agricultural and Biological Sciences | 30 | 39% |
| Medicine and Dentistry | 2 | 3% |
| Social Sciences | 1 | 1% |
| Unspecified | 1 | 1% |
| Other | 0 | 0% |
| Unknown | 11 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2022.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Cellular Signalling
#500
of 2,225 outputs
Outputs of similar age
#46,601
of 172,710 outputs
Outputs of similar age from Cellular Signalling
#5
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,225 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,710 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.