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A 500-kb Sequence-Ready Cosmid Contig and Transcript Map of theMEN1Region on 11q13

Overview of attention for article published in Genomics, January 1999
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Title
A 500-kb Sequence-Ready Cosmid Contig and Transcript Map of theMEN1Region on 11q13
Published in
Genomics, January 1999
DOI 10.1006/geno.1998.5625
Pubmed ID
Authors

Lee Bergman, Ginters Silins, Sean Grimmond, Holger Hummerich, Christine Stewart, Peter Little, Nicholas Hayward

Abstract

We have generated a transcript map of an approximately 1.2-Mb region from human chromosome band 11q13 between the loci VEGFB and CAPN1, which flank the multiple endocrine neoplasia type 1 (MEN 1) locus. In total, we isolated 144 cosmids from this region and generated a sequence-ready cosmid contig of the approximately 500-kb region between the neurexin locus and D11S2196E. We identified 54 genes/ESTs by sample sequencing and have constructed a transcript map of this region. Genes were found to be clustered in three regions, and one of these genes was identical to the recently identified MEN1 locus. Relative to the latter, we have mapped the positions of 13 known genes, 18 genes which show homology to genes from humans or other organisms, and 22 genes/ESTs that appear novel. In addition, we have ascertained the directions of transcription of some of these genes and have determined intergenic distances between many loci. Full characterization of some of these genes, as well as the novel ESTs, will be useful in identifying candidate genes for other diseases known to map to this chromosomal region.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 13%
Unknown 7 88%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 50%
Professor 2 25%
Student > Ph. D. Student 1 13%
Unknown 1 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 38%
Medicine and Dentistry 3 38%
Psychology 1 13%
Unknown 1 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Genomics
#2,112
of 5,923 outputs
Outputs of similar age
#24,657
of 109,586 outputs
Outputs of similar age from Genomics
#37
of 90 outputs
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